FIGURE

Fig. S3

ID

ZDB-FIG-241218-96

Publication

Ramakrishnan et al., 2025 - Real-time imaging reveals a role for macrophage protrusive motility in melanoma invasion

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Fig. S3

Effects of Rac2 on tumor invasion and macrophage motility at wounds. (A) Representative stills from time course images of wild-type larvae or larvae expressing mpx:mCherry-2A-rac2D57N injected with ZMel1 cells at 2 dpf. (B) Quantification of the number of invaded tumor cells at 48 hpi. (C) Quantification of macrophage recruitment at 24 and 48 hpi. wild-type (n = 18 larvae), mpx:mCherry-2A-rac2D57N (n = 20 larvae). Scale bar = 20 µm. (D) Representative stills of mpeg1:mCherry-2A-rac2WT or mpeg1:mCherry-2A-rac2E62K expressing larvae at 2 h post wound (hpw), tail transected at 3 dpf. (E) Quantification of macrophage recruitment to wound at 2 hpw. (F) Quantification of circularity of macrophages at the wound. mpeg1:mCherry-2A-rac2WT (n = 21 larvae, 219 cells), mpeg1:mCherry-2A-rac2E62K (n = 22 larvae, 207 cells) from two independent experiments. *P < 0.05, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Biol.