ZFIN Image: Ramakrishnan et al., 2025, Fig. S3

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Figure Caption

Fig. S3 Effects of Rac2 on tumor invasion and macrophage motility at wounds. (A) Representative stills from time course images of wild-type larvae or larvae expressing mpx:mCherry-2A-rac2D57N injected with ZMel1 cells at 2 dpf. (B) Quantification of the number of invaded tumor cells at 48 hpi. (C) Quantification of macrophage recruitment at 24 and 48 hpi. wild-type (n = 18 larvae), mpx:mCherry-2A-rac2D57N (n = 20 larvae). Scale bar = 20 �m. (D) Representative stills of mpeg1:mCherry-2A-rac2WT or mpeg1:mCherry-2A-rac2E62K expressing larvae at 2 h post wound (hpw), tail transected at 3 dpf. (E) Quantification of macrophage recruitment to wound at 2 hpw. (F) Quantification of circularity of macrophages at the wound. mpeg1:mCherry-2A-rac2WT (n = 21 larvae, 219 cells), mpeg1:mCherry-2A-rac2E62K (n = 22 larvae, 207 cells) from two independent experiments. *P < 0.05, **P < 0.01.

Acknowledgments

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