FIGURE

Fig. 6

ID

ZDB-FIG-241206-6

Publication

Smith et al., 2024 - Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment

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Fig. 6

Dual FGFR/VEGFR is not directly cytotoxic in dissociated AM PDX tumor cells. A Most AM cells cultured from PDX tumors do not grow in extended culture conditions. B Fresh PDX tumors were collected, dissociated into individual cells, and depleted of mouse stroma before plating for immediate and short term culture drug studies using quantitative phase imaging (QPI). Growth of AM and CM cells in (C) 0.5% DMSO; D 50 µM Sunitinib, E, 20 µM Lenvatinib, and (F) 40 µM Apatinib. G To facilitate comparison to PDX tumor growth velocity in Figs. 4B and D, growth velocity was calculated by linear regression of normalized mass

Expression Data

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Antibody Labeling

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.