FIGURE

Figure 7

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ZDB-FIG-241129-41
Publication
Wu et al., 2024 - Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action
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Figure 7

GPN treatment protects against delayed gentamicin damage but not acute neomycin damage. 250 μM GPN was added for 30 min before AG (purple bar), co-treated with neomycin for 1 h or co-treated with G418 for 1 h (red bar), rinsed, and incubated with GPN alone for 23 h (purple bar). (A) GPN treatment offers robust protection against delayed death from all concentrations of gentamicin (Two-way ANOVA, Sidak's multiple comparison, p < 0.0001). (B) GPN does not protect against acute death from neomycin at any concentration. n = 9–11 fish, 4 NMs/fish for each treatment group. Error bars represent Standard Deviation.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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