FIGURE

Figure 4

ID

ZDB-FIG-241129-38

Publication

Wu et al., 2024 - Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action

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Figure 4

The mitochondrially-targeted antioxidant mitoTEMPO protects against acute neomycin damage from neomycin but not delayed damage from G418. 50 μM mitoTEMPO was added for 30 min before AG (purple bar), co-treated with neomycin for 1 h or co-treated with G418 for 1 h (red bar), rinsed, and incubated with mitoTEMPO alone for 23 h (purple bar). (A) mitoTEMPO partially protected against damage from both 100 and 200 μM neomycin treatment. ****Two-way ANOVA, Sidak's multiple comparison, p < 0.0001. (B) mitoTEMPO offered no protection against damage from either 100 or 200 μM G418 treatment. ns Two-way ANOVA, Sidak's multiple comparison, p = 0.98. n = 9–11 fish, 4 NMs/fish for each treatment group. Error bars represent Standard Deviation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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