FIGURE

Figure 1

ID

ZDB-FIG-241114-32

Publication

Aguilera-Correa et al., 2024 - A dTDP-L-Rhamnose 4-epimerase required for glycopeptidolipid biosynthesis in Mycobacterium abscessus

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Figure 1

MAB_4111c belongs to the GPL biosynthetic cluster and is a predicted epimerase.A, structure of diglycosylated (GPL-2a) and triglycosylated (GPL-3) glycopeptidolipids. The green, blue, and yellow shadings represent the lipid, peptide, and glycosydic moieties of the GPL. Di-O-acetyl 6-d-Tal is drawn in red. B, Mycobacterium abscessus gpl locus encoding enzymes involved in the synthesis, modification, and transport of GPL. MAB_4111c is indicated in bold. C, alignment of the protein sequence of dTDP-L-Rha 4-epimerase from the Burkholderia thailandensis (ATCC 700388) (wbiB_BURTA) with that of MAB_4111c from M. abscessus. The orange and blue shadings represent the nonconserved and conserved and amino acids, respectively. The red, green, and blue asterisks indicate residues involved in the putative NADH-binding site, the substrate-binding site, and the catalytic residue reported in B. thailandensis, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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