FIGURE

Fig. 4

ID

ZDB-FIG-241028-57

Publication

Wang et al., 2024 - The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults

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Fig. 4

Microglial invasion and anti-inflammatory effects following treatment with XAL-NPMOF. (A) 4C4 staining of sections taken from retinas in the PBS, NPMOF, XAL and XAL-NPMOF groups at 1, 2, 3 and 4 dpl. The 4C4-positive cells are shown in red. (B) Quantification of the area of microglia in the lesioned retina (ANOVA, *p < 0.05). (C) The expression of tnf? and il1? mRNA at 24 hpl in the PBS, NPMOF, XAL and XAL-NPMOF groups (ANOVA, *p < 0.05). (D) Quantification of TNF-? and IL1? expression at 24 hpl via ELISA (ANOVA, *p < 0.05). (E) The expression of sod1 and sod2 mRNA at 24 hpl (ANOVA, *p < 0.05). (F) Quantification of Sod1 and Sod2 expression at 24 hpl via ELISA (ANOVA, *p < 0.05). Scale bar in (A): 50 ?m. Abbreviations: dpl, days post lesion; RPE, retinal pigment epithelium; OSL, outer segment layer; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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