PUBLICATION
The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults
- Authors
- Wang, Y., Yuan, B., Liu, W., Cui, J., Zhou, X., Yuan, L., Deng, Z., Li, Y., Yuan, X.
- ID
- ZDB-PUB-241022-5
- Date
- 2024
- Source
- International Journal of Nanomedicine 19: 103871040010387-10400 (Journal)
- Registered Authors
- Cui, Jianlin, Li, Yuhao
- Keywords
- anti-inflammatory effect, nanoscale zirconium-porphyrin metal-organic framework, photoreceptor, regeneration, xaliproden
- MeSH Terms
-
- Metal-Organic Frameworks*/chemistry
- Metal-Organic Frameworks*/pharmacology
- Zebrafish*
- Nanoparticles/chemistry
- Inflammation/drug therapy
- Zirconium*/chemistry
- Zirconium*/pharmacology
- Animals
- Photoreceptor Cells, Vertebrate/drug effects
- Human Umbilical Vein Endothelial Cells*/drug effects
- Porphyrins*/chemistry
- Porphyrins*/pharmacology
- Oxidative Stress/drug effects
- Macular Degeneration/drug therapy
- Humans
- Regeneration*/drug effects
- PubMed
- 39430310 Full text @ Int. J. Nanomedicine
Citation
Wang, Y., Yuan, B., Liu, W., Cui, J., Zhou, X., Yuan, L., Deng, Z., Li, Y., Yuan, X. (2024) The Xaliproden Nanoscale Zirconium-Porphyrin Metal-Organic Framework (XAL-NPMOF) Promotes Photoreceptor Regeneration Following Oxidative and Inflammatory Insults. International Journal of Nanomedicine. 19:103871040010387-10400.
Abstract
Background Age-related macular degeneration (AMD) is becoming the leading cause of blindness in the aged population. The death of photoreceptors is the principal event which is lack of curative treatment. Xaliproden, a highly selective synthetic 5-OH-tryptamine (5HT) 1A receptor agonist, has the neuroprotective potential. However, its application has been limited by the insoluble formulation, low utilization efficiency and side effects caused by systemic administration.
Methods Nanoscale zirconium-porphyrin metal-organic framework (NPMOF) was used as a skeleton and loaded with xaliproden (XAL) to prepare a novel kind of nanoparticle, namely, XAL-NPMOF. The human umbilical vein endothelial cells, zebrafish embryos and larvae were used to test the biotoxicity and fluorescence imaging capability of XAL-NPMOF both in vitro and in vivo. A photoreceptor degeneration model was generated by intense light injury in adult zebrafish and XAL-NPMOF was delivered to the injured retina by intraocular injection. The photoreceptor regeneration, inflammatory response and visual function were explored by immunohistochemistry, quantitative real-time polymerase chain reaction and optomotor response analysis.
Results Following a single XAL-NPMOF intraocular injection, the injured retina underwent the faster photoreceptor regeneration with a recovery of visual function via promoting cell proliferation, suppressing the inflammatory responses and increasing the expression of antioxidases.
Conclusion As an amplifier, NPMOF can enhance the anti-inflammatory efficacy and neuroprotective effect of xaliproden. XAL-NPMOF could be a novel and convenient option for the treatment of AMD.
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Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping