FIGURE

Fig. 2

ID

ZDB-FIG-241022-28

Publication

Singer et al., 2024 - Ultrahigh field diffusion magnetic resonance imaging uncovers intriguing microstructural changes in the adult zebrafish brain caused by Toll-like receptor 2 genomic deletion

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

T2 relaxation time and ADC measurement in various brain regions of control and tlr2 mutant (tlr2?/?) zebrafish. (A) Anatomical DWI (b-value 1000 s/mm2), sagittal slice, showing ROIs used for T2 and ADC estimation. (B) Estimated T2 relaxation times in selected ROIs of control and tlr2?/? zebrafish. (C) Estimated ADC in selected ROIs of control and tlr2?/? zebrafish. Acquisition details for MSME: TR 3000, ? 6.0 ms, 4 averages, resolution 47 � 47 ?m and a slice thickness of 500 ?m; and for DWI: TR 1000 ms, TE 13 ms, 4 averages, resolution 47 � 47 ?m, slice thickness 200 ?m and effective b-value range 50, 500, 1000, 1500, 2000, 2500 or 3000 s/mm2. Statistical analysis was performed using the unpaired t-test, assuming Gaussian distribution, with p less than 0.05 considered to imply significant differences between the control and the tlr2?/? group. *p < 0.05, **p < 0.01, ****p < 0.001. ADC, apparent diffusion coefficient; CCeg, granular layer of the cerebellar corpus; CCem, molecular layer of the cerebellar corpus; DIL, diffuse nucleus of the inferior lobe; DM, medial zone of the dorsal telencephalon; DWI, diffusion-weighted imaging; MLF, medial longitudinal fascicle; MSME, multislice multiecho; ROI, region of interest; TL, longitudinal torus.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NMR Biomed.