FIGURE

FIGURE 4

ID

ZDB-FIG-241017-107

Publication

Lee et al., 2024 - Transgenic zebrafish as a model for investigating diabetic peripheral neuropathy: investigation of the role of insulin signaling

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FIGURE 4

Depletion of insulin production elevates glucose levels, but not ROS, in ins:epNTR-mCherry zebrafish. (A) Quantification of the glucose levels (mg/dL) in Ins:epNTR-mCherry larvae treated with DMSO and MTZ at 9 dpf, ****p < 0.0001, t-test (n = 20 larvae per one data point, total n = 100 larvae per group). (B) Quantification of the ROS intensity in the PLLg cells of Ins:epNTR-mCherry expressing Tg (tubb2b:dsred) larvae presented in panels (D’) and (E’) (n = 10 larvae per group). (C) Quantification of the number of PLLg cells of the transgenic larvae presented in panels (D”) and (E”) (n = 11 larvae per group). (D–E”)In-vivo fluorescence images showing PLLg cell and CellROX ROS detector in the transgenic larvae treated with DMSO (D–D”) or MTZ (E–E”) at 9 dpf. Scale bar, 20 μm in (D).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.