FIGURE

FIGURE 1

ID

ZDB-FIG-241017-103

Publication

Lee et al., 2024 - Transgenic zebrafish as a model for investigating diabetic peripheral neuropathy: investigation of the role of insulin signaling

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FIGURE 1

Ablation of pancreatic β-cells induced depletion of insulin production in ins:epNTR-mCherry zebrafish. (A) Schematics of the transgenic zebrafish showing the ablation of pancreatic β-cells using epNTR-mediated chemogenetic ablation system. (B,C) In-vivo fluorescence images showing pancreatic β-cells in Ins:epNTR-mCherry larvae treated with DMSO (B) and MTZ (C) at 9 dpf. (D) Quantification of fluorescence intensity in mcherry-expressing pancreatic β-cells from panel (B) and (C), ****p < 0.0001, t-test (n = 12 larvae per group). (E) Quantification of expression of ins mRNA in transgenic larvae, ****p < 0.0001, t-test (n = 15 larvae per group). Scale bar, 20 μm in (B).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.