Fig. 6
- ID
- ZDB-FIG-241016-32
- Publication
- Wang et al., 2024 - Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal
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Foxo1a gain of function can partially rescue the excessive angiogenesis induced by high glucose treatment. (a) A diagram showing the high glucose treatment time window and heat shock-treated time point. (b) Confocal imaging analysis of blood vessels in control Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. (c) Confocal imaging analysis of blood vessels in high glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. (d?d?) Confocal imaging analysis of blood vessels in hsp70l:foxo1a-P2A-mCherry and high glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. (e) Statistical analysis of the total length of intersegmental vessels (ISVs) in control, high glucose-treated, hsp70l:foxo1a-P2A-mCherry, and high glucose-treated embryos (n=6), respectively. One-way ANOVA, ****p<0.0001. (f) A diagram showing the high glucose treatment time window and imaging time point. (g) Confocal imaging analysis of blood vessels in high glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. (h) Confocal imaging analysis of blood vessels in fli1EP:foxo1a-mApple and high glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. (i) Statistical analysis of the number of sprouts per ISV in high glucose-treated embryos, and fli1EP:foxo1a-mApple and high glucose-treated embryos (n=9). t-test, ****p<0.0001. (j) Statistical analysis of the total length of ISVs in high glucose-treated embryos, and fli1EP:foxo1a-mApple and high glucose-treated embryos (n=8). t-test, ***p<0.001. |