Fig. 5
- ID
- ZDB-FIG-241016-31
- Publication
- Wang et al., 2024 - Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal
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Foxo1a was involved in the excessive angiogenesis induced by high glucose treatment. (a) The volcano plot of differential expression genes in arterial and capillary endothelial cells (ECs). The avg_log2FC greater than 1 was considered significant, including 523 downregulated genes (blue dots) and 1201 upregulated genes (red dots). (b) Gene ontology (GO) analysis of 523 downregulated genes in arterial and capillary ECs. (c) The feature plot of ECs marker gene pecam1 of control and high glucose group in arterial and capillary ECs. (c?) The violin plot of ECs marker gene pecam1 of control and high glucose group in arterial and capillary ECs. (d) The feature plot of gene foxo1a of control and high glucose group in arterial and capillary ECs. (d?) The violin plot of gene foxo1a of control and high glucose group in arterial and capillary ECs. (e) Average expression of gene pecam1 and foxo1a in control and high glucose group. (f) Whole-mount in situ hybridization analysis of foxo1a in control, high glucose-, and high L-glucose-treated embryos. (g) A diagram showing the foxo1 inhibitor treatment time window. (h) Confocal imaging analysis of control embryos, AS1842856-treated embryos, and foxo1a MO-injected embryos. Arrowheads indicate ectopic angiogenic sprouts. (i) Statistical analysis of the total length of intersegmental vessels (ISVs) in control embryos, AS1842856-treated embryos, and foxo1a MO-injected embryos (n=5). t-test, ****p<0.0001. |