Fig. 3
- ID
- ZDB-FIG-241016-25
- Publication
- Wang et al., 2024 - Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal
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- Fig. 1
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High glucose treatment induced endothelial differentiation into tip cell-like cells. (a) A diagram showing the confocal time-lapse imaging time window. (b) A diagram indicating the imaging position of the zebrafish embryos. (c) Confocal time-lapse imaging analysis of blood vessels in control Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. (d) A diagram showing the glucose treatment time window and confocal time-lapse imaging time window. (e) Confocal time-lapse imaging analysis of blood vessels in glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. Arrowheads indicate the ectopic angiogenic branches. (f) A snapshot of confocal time-lapse imaging analysis of blood vessels in glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. Z stacks were used to make 3D color projections, where blue represents the most proximal (closest to the viewer), and red represents the most distal (farthest from the viewer). Arrowheads indicate ectopic angiogenic sprouts. (g) A snapshot of confocal time-lapse imaging analysis of an intersegmental vessel (ISV) in glucose-treated Tg(fli1aEP:EGFP-CAAX)ntu666 embryos. Arrowheads indicate ectopic angiogenic sprouts. (h-j’) The feature plot of tip cell marker genes esm1, apln and cxcr4a of control and high glucose group in arterial and capillary ECs. (k) The violin plot of tip cell marker genes esm1, apln and cxcr4a of control and high glucose group in arterial and capillary ECs |