Fig. 1

Elevated ADAMTS1 expression in renal cell carcinoma (RCC) tissues is associated with a poor prognosis. A ADAMTS1 mRNA levels in RCC tissues were significantly higher than those in normal renal tissues (p = 0.033) as determined by TNMplot (https://tnmplot.com/analysis/). B ADAMTS1 expression was assessed in 72 matched clear cell (cc)RCC tissues and their corresponding normal tissues using data from the GSE53757 ccRCC expression microarray dataset. C The left panel of the Uniform Manifold Approximation and Projection (UMAP) plot illustrates the distribution of tumor cells and benign epithelial cells based on single-cell RNA sequencing (scRNA-seq) profiles. The UMAP plot in the middle panel shows the expression distribution of ADAMTS1. The violin plot in right panel indicates that ADAMTS1 exhibits a significant elevation in tumor cells compared with benign epithelial cells, with a fold change (FC) of 1.27 and a false discovery rate (FDR) of less than 0.01. D Kaplan–Meier analysis depicts overall survival (OS) rates in patients with ccRCC based on high or low ADAMTS1 expression using data from TCGA