FIGURE

Fig 3

ID

ZDB-FIG-240921-3

Publication

Ibarra-García-Padilla et al., 2024 - Expansion of a neural crest gene signature following ectopic MYCN expression in sympathoadrenal lineage cells in vivo

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Fig 3

MYCN overexpression in SAP cells leads to sox10 reporter activity expansion in vivo.

A-F) Confocal images of the developing SCG from different time points during live imaging of sox10:mRFP;dbh:EGFP (A,C,E), or sox10:mRFP;dbh:EGFP-MYCN (B,D,F) larvae from ~70 hpf to ~118 hpf. Markers: EGFP (green), sox10 reporter: mRFP (magenta), and coloc channel (yellow). sox10 reporter expression of mRFP within the developing SCG is visible in MYCN-EGFP overexpressing larvae (B’,D’, F’) compared to EGFP control larvae, (A’, C’, E’) with higher reporter levels at earlier timepoints. Scale bars = 50 μm for uncropped images, 20 μm for cropped images.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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