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Fig. 4

ID

ZDB-FIG-240906-4

Publication

Wang et al., 2024 - Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet

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Fig. 4

Slc25a1 inhibition attenuates high-fat diet (HFD)-induced abnormal hepatic lipid deposition by enhancing oxidative catabolism. A: hepatic triglyceride(TAG) content in zebrafish (n = 6). B: hepatic nonesterified fatty acid (NEFA) content in zebrafish (n = 6). C–F: mRNA expression of hepatic liposynthesis- and lipid catabolism-related genes in zebrafish (n = 5–7). G and I: protein expression of hepatic carnitine palmitoyltransferase 1a (Cpt1a) in zebrafish and Nile tilapia (n = 2–3). H: hepatic TAG content in Nile tilapia (n = 6). J and K: rate of [1-14C]- palmitic acid (PA) oxidation in vitro and in vivo (n = 3 and 6, respectively). L: lipid metabolism patterns after inhibition of Slc25a1 under HFD. Values are means ± SD. The asterisk symbol indicates significant differences from the control treatment at *P < 0.05, **P < 0.01, ***P < 0.001 (independent-sample t test). Figure created with BioRender.com.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Physiol. Cell Physiol.