FIGURE

Fig. 6

ID

ZDB-FIG-240906-12

Publication

Wang et al., 2024 - ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

The damaging CCDC141 rare variant in patients with laterality defects. A: The genomic location and the amino acid changes of the four CCDC141 variants. B: CCDC141 proteins alignment highlighting the conservation of the affected amino acids in patients with laterality defects (yellow). C?E: The abnormal cardiac looping, pericardial edema, and curved tail in the ccdc141 crispants embryos. N = 3; n = 201/293/128/257 (C). N = 5 (D and E). ????, P < 0.0001; ns, no significance; two-sided Fisher's exact test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Journal of genetics and genomics = Yi chuan xue bao, 51(9), Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R., ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish, 934-946, Copyright (2024) with permission from Elsevier. Full text @ J. Genet. Genomics