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Fig. 6 The damaging CCDC141 rare variant in patients with laterality defects. A: The genomic location and the amino acid changes of the four CCDC141 variants. B: CCDC141 proteins alignment highlighting the conservation of the affected amino acids in patients with laterality defects (yellow). C?E: The abnormal cardiac looping, pericardial edema, and curved tail in the ccdc141 crispants embryos. N = 3; n = 201/293/128/257 (C). N = 5 (D and E). ????, P < 0.0001; ns, no significance; two-sided Fisher's exact test.
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Reprinted from Journal of genetics and genomics = Yi chuan xue bao, 51(9), Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R., ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish, 934-946, Copyright (2024) with permission from Elsevier. Full text @ J. Genet. Genomics