FIGURE
Fig. 4
- ID
- ZDB-FIG-240904-9
- Publication
- Monaghan et al., 2024 - FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms
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Fig. 4
Distinct transcriptomic profiles of primary human ECs expressing both types of TOF variants compared with WT or an MD FLT4. (A) Distribution of DEGs between HUVECs expressing FLT4-V5 WT, FLT4 R1041P (MD), and FLT4 TOF-DNV (C51W) or FLT4-TOF-PTV (1-736Q*), identified by RNAseq. (B) Reactome analysis of the 702 TOF FLT4-specific DEGs, up- or down-regulated examined separately, displaying pathways identified with FDR < 0.01. (C) Volcano plot showing the 702 FLT4 TOF-specific DEGs, with genes taken forward for qPCR analysis labelled, and those previously associated with CHD in red. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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