FIGURE

Fig. 6

ID

ZDB-FIG-240828-43

Publication

Caetano da Silva et al., 2024 - Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis

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Fig. 6

Over-expression of ctnnd1 rescues esrp1?/?, esrp2?/? epithelial phenotypes.A Image representing how wildtype, intermediate and cleft ANC, pectoral fins and otoliths were sorted. B Representative table with the number of total fish injected and rescued by the ctnnd1 mRNA injection with GFP mRNA injection as control. Scoring of ANC phenotype (%) (C), fin phenotype (%) (D) and the otolith phenotype (%) (E) in the injected esrp1?/?; esrp2+/? inter-cross larvae confirmed by genotyping, showing 20?22% rescue of ANC, fin and otolith phenotypes in the esrp1?/?; esrp2?/? double homozygous larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	esrp1^fb401/fb401 esrp1^fb401/fb401; esrp2^fb402/fb402
Observed In:	ceratohyal cartilage Meckel's cartilage otolith pectoral fin
Stage:	Day 4

Phenotype Detail

Acknowledgments

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