FIGURE

Fig. 3

ID

ZDB-FIG-240814-5

Publication

Emmerich et al., 2024 - Large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration

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Fig. 3

Pseudotime trajectory analysis of RGC and rod PR regeneration paradigms. (A) UMAP used to create pseudotime trajectory of MG>progenitor>RGC cells using 0-72 hpa data. (B) Density of unablated (Cntr) and RGC ablated (+Mtz) cells along the trajectory in A. (C) Expression of atoh7 and ascl1a in Cntr (black line) and RGC-ablated data (red line) along trajectory in A. (D) Heatmap of selected DEGs upregulated during RGC loss and regeneration. (E) UMAP used to create pseudotime trajectory of MG>progenitors>rods using 48 hpa data. (F) Density of unablated (Cntr) and rod-ablated (+Mtz) cells along the trajectory in E. (G) Expression of atoh7 and ascl1a in Cntr (black line) and rod-ablated (red line) data along the trajectory in E. (H) Comparison of changes in expression of selected neurogenic genes between RGC ablation (top series) or rod cell ablation (bottom series) paradigms along corresponding pseudotime trajectories.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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