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FIGURE 4

ID

ZDB-FIG-240813-6

Publication

Zhang et al., 2024 - CM082 suppresses hypoxia-induced retinal neovascularization in larval zebrafish

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FIGURE 4

CM082 inhibited the expression of vegfr2 in the eyes of zebrafish larvae under hypoxia. (A–D) qRT-PCR analysis of hif1α, vegfr1, vegfr2 and vegfr3 in eight groups. (A, B, D) The results showed higher hif1α, vegfr1 and vegfr3 mRNA levels in hypoxia than normoxia. CM082 did not further altered the mRNA level. (C) The expression of vegfr2 was significantly upregulated under hypoxia, and downregulated by CM082. (E) Western blots of p-Vegfr2 and Gapdh. p-Vegfr2, 220 kD; Gapdh, 36 kD. (F) The expression of p-Vegfr2 was significantly upregulated under hypoxia, then downregulated by CM082. *p < 0.05; **p < 0.01; ***p < 0.001. Data represent the mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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