Fig. 6
- ID
- ZDB-FIG-240806-47
- Publication
- Jiang et al., 2024 - Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility
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ttna?9/?9 zebrafish embryos exhibit ANP upregulation and ANP-dependent changes in IKs channel components and atrial function (A) Quantification of mRNA levels for nppa, kcnq1, and kcne1 in zebrafish embryos at 48 hpf. Each dot represents a biological replicate, and each replicate contains 5?10 embryos. (B) Quantification of mRNA levels for kcne1 in negative control morpholino (Control MO)-treated or morpholino targeting nppa (nppa MO)-treated ttna?9/?9 zebrafish embryos at 48 hpf. Each data point represents a biological replicate, and each replicate contains 5?10 embryos. (C) Quantification for atrial contraction of Control MO-treated (n = 47) or nppa MO-treated (n = 38) ttna?9/?9 zebrafish embryos at 48 hpf. (D) Quantification for atrial contraction of Control MO-treated (n = 19) or nppa MO-treated (n = 17) ttna+/+ zebrafish embryos at 48 hpf. (E) Quantification of ventricular contraction of Control MO-treated (n = 26) or nppa MO-treated (n = 17) ttna?9/?9 zebrafish embryos at 48 hpf. Data are represented as mean ±95% confidence intervals. ns p > 0.05; ?p < 0.05; ???p < 0.001; ????p < 0.0001. See also Figures S9 and S10 . |