FIGURE

Fig. 4

ID

ZDB-FIG-240806-45

Publication

Jiang et al., 2024 - Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

ttna?9/?9 zebrafish atria and TTN?9/?9-hiPSC-aCMs exhibit reduced atrial contractility (A) Quantification of atrial contraction for ttna+/+ (n = 20), ttna?9/+ (n = 39), and ttna?9/?9 (n = 33) embryos at 48, 72, and 96 hpf. (B and C) Representative recordings of the contraction of TTN+/+-hiPSC-aCMs and TTN?9/?9-hiPSC-aCMs. (D?G) Quantification of contraction frequency (D), displacement (E), wave component duration (F), and maximal velocity (G) during contraction and relaxation of hiPSC-aCMs (n = 3 independent batches, n = 3 biological replicates per batch). Data in (A, D?G) are represented as mean �95% confidence intervals. ns p > 0.05; ??p < 0.01; ???p < 0.001; ????p < 0.0001. See also Figure S7 and Table S1 .

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience