FIGURE

Fig. 4

ID

ZDB-FIG-240806-45

Publication

Jiang et al., 2024 - Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility

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Fig. 4

ttnaΔ9/Δ9 zebrafish atria and TTNΔ9/Δ9-hiPSC-aCMs exhibit reduced atrial contractility (A) Quantification of atrial contraction for ttna+/+ (n = 20), ttnaΔ9/+ (n = 39), and ttnaΔ9/Δ9 (n = 33) embryos at 48, 72, and 96 hpf. (B and C) Representative recordings of the contraction of TTN+/+-hiPSC-aCMs and TTNΔ9/Δ9-hiPSC-aCMs. (D–G) Quantification of contraction frequency (D), displacement (E), wave component duration (F), and maximal velocity (G) during contraction and relaxation of hiPSC-aCMs (n = 3 independent batches, n = 3 biological replicates per batch). Data in (A, D–G) are represented as mean ±95% confidence intervals. ns p > 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001. See also Figure S7 and Table S1 .

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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