FIGURE

Figure 6

ID

ZDB-FIG-240729-272

Publication

Wei et al., 2024 - In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells

Other Figures

All Figure Page

Back to All Figure Page

Figure 6

Ethacrynic acid causes less damage to normal hematopoiesis than ATRA. (A) DIC images of zebrafish WT embryos at 3 and 4 dpf after treatment with ATRA (0.1 μM) and ethacrynic acid (20 μM) at 24 hpf. (B) WISH of cmyb, mpx, and rag1 in WT embryos at 3 and 4 dpf after treatment with ATRA and ethacrynic acid at 24 hpf. A green arrow indicates the staining signal. (C) SB and NR staining of WT embryos at 4 dpf after chemical treatment. Results are represented as mean ± SEM, n = 3, t-test; *** p < 0.001, **** p < 0.0001; ns, not significant. (D) Benzidine staining of WT embryos at 4 dpf after chemical treatment. SB, Sudan black; NR, neutral red.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.