FIGURE

Figure 3

ID

ZDB-FIG-240729-269

Publication

Wei et al., 2024 - In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells

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Figure 3

The four identified compounds induce myeloid differentiation of U937 cells. (A–D) Flow cytometry analysis of CD14 and CD11b expression in U937 cells treated with different doses of ethacrynic acid, oxcarbazepine, alendronate, and khellin. (E) Flow cytometry analysis of CD14 and CD11b expression in U937 cells treated with 30 μM ethacrynic acid, oxcarbazepine, alendronate, and khellin for 3 days. (F) Representative images of May-Grunwald-Giemsa staining at 200× magnification of U937 cells treated with 30 μM chemicals for 3 days. Green arrows indicate undifferentiated cells and red arrows indicate mature cells. (G) The proliferation curve of U937 cells treated with ethacrynic acid (30 μM). Results are represented as mean ± SEM, n = 3, t-test; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p< 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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