FIGURE

Fig. 4

ID

ZDB-FIG-240725-23

Publication

Gutsfeld et al., 2024 - Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)

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Fig. 4

Experimental design for exploratory RNA-seq. Head dissections of PFOS (0.88μ⁢M, 1.57μ⁢M, 2.8μ⁢M) or PFHxS (7.87μ⁢M, 14μ⁢M, 25.1μ⁢M)-exposed larvae were conducted on 4–5 dpf for RNA-seq with five biological replicates per condition. Differentially expressed genes (DEGs) were used for functional enrichment analysis using ToxNodes in SOM-format, calculation of transcriptomic benchmark concentrations (BMCT), and upstream regulator predictions via an Ingenuity Pathway Analysis. Note: dpf, days postfertilization; PFHxS, perfluorohexanesulfonic acid; PFOS, perfluorooctanesulfonic acid; RNA-seq, RNA sequencing; SOM, self-organizing map.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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