FIGURE

Fig. 6

ID

ZDB-FIG-240720-6

Publication

de Sousa et al., 2024 - Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Cerebral (A, B) and ocular cerebral parasite load (C, D) of dams (A, C) and non-pregnant mice (B, D) infected with 100 oocysts of TgShSp1 strain and treated with BKI-1708 at 20 mg/kg/day for 5 days, or with corn oil as placebo (Positive control). Negative control was not infected and treated with corn oil. Eyes and brains were removed after euthanasia and T. gondii DNA was extracted and quantified by real-time PCR. Values are shown as box plots. Parasite burden between groups were compared using the Kruskal-Wallis test, followed by the Mann-Whitney-U test. Differences between BKI-1708-treated with 20 mg/kg and non-treated groups were statistically significant in non-pregnant mice and dams. (A) *P = 0.0328; **P = 0.0042, ***P = 0.0003; (B) *P = 0.0018; (C) **P = 0.0042; ***P = 0.0001; (D) **P = 0.005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int J Parasitol Drugs Drug Resist