FIGURE

Fig. 7

ID

ZDB-FIG-240720-7

Publication

de Sousa et al., 2024 - Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice

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Fig. 7

BKI-1708 treatment in the pregnant neosporosis mouse model. BALB/c mice were experimentally infected with 10⁵ NcSpain-7 tachyzoites and treated with BKI-1708 for 5 days at 20 mg/kg/day or with corn oil as placebo (Positive control). Negative control (C-) was not infected and treated with corn oil. A shows Kaplan-Meier survival curves of pups, curves were compared by the Logrank (Mantel-Cox) test. Differences between treated group and C+ curves were highly significant (P < 0.0001). Cerebral parasite burdens in dams (B) and non-pregnant mice (C) were quantified by real time PCR and are shown as box plots. Significant differences in the cerebral parasite burden were observed between BKI-1708-treated mice compared to the C+ group. (B) ****P = 0.0001; (C) **P = 0.0005.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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