FIGURE

Fig. 6

ID

ZDB-FIG-240715-84

Publication

Roisman-Geller et al., 2024 - Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish

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Fig. 6

Reduced pomca-driven expression in corticotrophs of adult lhx4 mutants. (A) Tg(pomca:GFP) reporter line was utilized for evaluating corticotroph development in 4-month-old lhx4 mutants (N = 21) and their WT siblings (N = 18). The integrated fluorescence in the pituitaries of homozygous lhx4 mutants was reduced (* p < 0.05, t-test) as compared with that of their WT siblings. (B) Representative pomca promoter-driven fluorescence in the pituitaries of adult WT (left) and homozygous lhx4 mutant (right). Scale bar = 100 µm.

Expression Data

Gene:	GFP
Fish:	zf44Tg/+ lhx4^tlv12/tlv12; zf44Tg/+
Anatomical Term:	hypophysis
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lhx4^tlv12/tlv12; zf44Tg/+
Observed In:	hypophysis
Stage:	Adult

Phenotype Detail

Acknowledgments

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