FIGURE

Fig. 7

ID

ZDB-FIG-240715-85

Publication

Roisman-Geller et al., 2024 - Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish

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Fig. 7

Immature ovaries and depleted gonadotrophs in lhx4 KO females. (A) Hematoxylin and eosin histology performed on adult fish ovary sections, demonstrating an undeveloped ovary of homozygous lhx4-mutant female (top), compared with a properly developed WT sibling ovary (bottom). Scale bar = 200 µm. (B) Expression of RFP under the tilapia lhb promoter in the pituitary of adult WT sibling female (left) and homozygous lhx4-mutant female (right), indicating severely impaired gonadotroph development in the mutant. Scale bar = 100 µm.

Expression Data

Gene:	TagRFP
Fish:	hjr3Tg/+ lhx4^tlv12/tlv12; hjr3Tg/+
Anatomical Term:	hypophysis
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lhx4^tlv12/tlv12 lhx4^tlv12/tlv12; hjr3Tg/+
Observed In:	hypophysis ovarian follicle ovary
Stage:	Adult

Phenotype Detail

Acknowledgments

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