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Fig. 6 Reduced pomca-driven expression in corticotrophs of adult lhx4 mutants. (A) Tg(pomca:GFP) reporter line was utilized for evaluating corticotroph development in 4-month-old lhx4 mutants (N = 21) and their WT siblings (N = 18). The integrated fluorescence in the pituitaries of homozygous lhx4 mutants was reduced (* p < 0.05, t-test) as compared with that of their WT siblings. (B) Representative pomca promoter-driven fluorescence in the pituitaries of adult WT (left) and homozygous lhx4 mutant (right). Scale bar = 100 µm.
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Full text @ Int. J. Mol. Sci.