FIGURE

Fig. 5

ID

ZDB-FIG-240708-44

Publication

McKaige et al., 2024 - Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model

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Fig. 5

Double dnajb6 mutants show mitochondrial abnormalities. (A) Electron microscopy of double mutant and wildtype muscle at 6 dpf shows no visible difference between double dnajb6 mutants and wildtype. (B) Ultrastructure of 3 mpf double mutant and wildtype muscle reveals mitochondria with abnormal cristae arrangement (arrow). (C) Quantification of mitochondrial abnormalities at 6 dpf and 3 mpf. At 6 dpf there was no sign of mitochondrial abnormalities in double mutants. However, at 3 mpf there was a significant increase in the proportion of abnormal mitochondria in double mutants compared to wildtype (P < 0.001, based on a binomial test). Analysis at both timepoints was completed blinded with two biological replicates and n = 4 per genotype.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnajb6a^mnu13/mnu13; dnajb6b^mnu14/mnu14 (TU)
Observed In:	skeletal muscle mitochondrial crista skeletal muscle mitochondrion
Stage Range:	Day 6 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.