FIGURE

Fig. 2

ID

ZDB-FIG-240708-41

Publication

McKaige et al., 2024 - Mitochondrial abnormalities contribute to muscle weakness in a Dnajb6 deficient zebrafish model

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Fig. 2

Double dnajb6 mutant zebrafish do not show signs of myopathy during early development. (A) Immunofluorescence staining of methyl cellulose treated dnajb6 mutants and their siblings with anti-myosin at 1 dpf. Larvae were incubated in methyl cellulose for 1 h prior to fixation. Maximum projection confocal images were taken laterally of the trunk above the egg yolk extension. (B) Images show examples of the phenotype scored. Quantification and analysis of the fibre damage phenotype showed no significant differences between genotypes (P > 0.05, binomial test). Analysis was completed with n ≥ 28 per genotype.

Expression Data

Antibody:	Ab-A4.1025
Fish:	TU dnajb6a^mnu13/mnu13 (TU) dnajb6b^mnu14/mnu14 (TU) dnajb6a^mnu13/mnu13; dnajb6b^mnu14/mnu14 (TU)
Condition:	chemical treatment by environment: methyl cellulose
Anatomical Term:	skeletal muscle cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnajb6a^mnu13/mnu13 (TU) dnajb6b^mnu14/mnu14 (TU) dnajb6a^mnu13/mnu13; dnajb6b^mnu14/mnu14 (TU)
Condition:	chemical treatment by environment: methyl cellulose
Observed In:	skeletal muscle cell
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.