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Fig. 4

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ZDB-FIG-240703-69

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Choleva et al., 2024 - Targeting the interaction of pleiotrophin and VEGFA₁₆₅ with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis

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Fig. 4

PTN97–110 affects angiogenesis in the zebrafish. (A) (a–d) Images illustrating the blood vessels at 72 hpf Tg(kdrl:GFP)s843 control and embryos injected with the zebrafish peptide, as seen from a left lateral. The dashed boxed regions are displayed at higher magnification in panels (a’-d’). (a’-d’) Higher magnifications of blood vessels in specified boxes. Injected embryos revealed a disorganized blood vessel arrangement in the head (c’), eye (c’’), ISV, and DLAV (d’’). Scale bar 200 μm. (e) Percentage of control and zebrafish PTN97-110 injected embryos with disorganized blood vessels. (B) (a–d) Images illustrating the blood vessels at 72 hpf Tg(kdrl:GFP)s843 control and injected embryos with the human peptide, as seen from a left lateral. The dashed boxed regions are displayed at higher magnification in panels (a’-d’). (a’-d’) Higher magnifications of blood vessels in specified boxes. Injected embryos revealed a disorganized blood vessel arrangement in the head (c’), eye (c’’), ISV, and DLAV (d’’). Scale bar 200 μm. (e) Percentage of control and human PTN97-110 injected embryos with disorganized blood vessels.

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Acknowledgments

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Reprinted from European Journal of Pharmacology, 977, Choleva, E., Menounou, L., Ntenekou, D., Kastana, P., Tzoupis, Η., Katraki-Pavlou, S., Drakopoulou, M., Spyropoulos, D., Andrikopoulou, A., Kanellopoulou, V., Enake, M.K., Beis, D., Papadimitriou, E., Targeting the interaction of pleiotrophin and VEGFA₁₆₅ with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis, 176692, Copyright (2024) with permission from Elsevier. Full text @ Eur. J. Pharmacol.