Fig. 2
- ID
- ZDB-FIG-240703-67
- Publication
- Choleva et al., 2024 - Targeting the interaction of pleiotrophin and VEGFA165 with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis
- Other Figures
- All Figure Page
- Back to All Figure Page
PTN97–110 inhibits PTN- and VEGFA165-induced endothelial cell migration and tube formation on Matrigel (A) Migration of HUVEC in the presence or absence of PTN (100 ng/ml), VEGFA165 (10 ng/ml) and/or PTN97-110 (100 ng/ml). Results are expressed as mean ± SD (n ≥ 4) of the percent number of migrated cells compared to the untreated cells (set as default 100%). (B) Representative photos and quantification of the tube network formed by HUVEC on Matrigel, in the presence or absence of PTN, VEGFA165, and/or PTN97-110. Results are expressed as mean ± SD (n = 5) of the percent total tube length compared to the untreated cells (set as default 100%). (C) Migration of Ptn+/+ and (D) Ptn−/− LMVEC in the presence or absence of PTN, VEGFA165, and/or PTN97-110. Results in C and D are expressed as mean ± SD (n ≥ 3) of the percent number of migrated cells compared to the corresponding untreated cells (set as default 100%). Asterisks denote statistical significance compared to the untreated cells. **P < 0.01, ***P < 0.001, ****P < 0.0001. |
Reprinted from European Journal of Pharmacology, 977, Choleva, E., Menounou, L., Ntenekou, D., Kastana, P., Tzoupis, Η., Katraki-Pavlou, S., Drakopoulou, M., Spyropoulos, D., Andrikopoulou, A., Kanellopoulou, V., Enake, M.K., Beis, D., Papadimitriou, E., Targeting the interaction of pleiotrophin and VEGFA165 with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis, 176692, Copyright (2024) with permission from Elsevier. Full text @ Eur. J. Pharmacol.