Fig. 1

The FOXP2-TAD contains two clusters of HARs. (A) Virtual Hi?C contact matrix obtained from midgestational developing human cortical plate (Won et al. 2016). FOXP2-alternative TSS interactions are showed as black lines over the matrix. (B) Diagram obtained from UCSC Genome Browser showing the FOXP2 locus on chromosome 7 (7q31.1) of the human genome (hg19). FOXP2-TSSs are indicated as blue bars. HARs genome coordinates were obtained from an assembly of available HARs (Capra et al. 2013), and each element conserved its name from the original database that generated it (Pollard, Salama, Lambert, et al. 2006; Prabhakar et al. 2006; Bird et al. 2007; Lindblad-Toh et al. 2011). HARs are indicated by gray bars. Active elements from this study are in red, while non-active HARs are in blue. Cluster 1 contains seven HARs (light orange block). Cluster 2 contains five HARs located downstream to the FOXP2 locus (light blue block). (C) The whole region is located inside the same TAD, and this topological region seems to be conserved through several tissues (Schmitt et al. 2016; Won et al. 2016).