FIGURE

Figure 2

ID

ZDB-FIG-240620-276

Publication

Aranda-Mart�nez et al., 2024 - Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty

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Figure 2

Histological and morphometric changes of zebrafish skeletal muscle. (A) Light microscopy images of longitudinal sections stained with hematoxylin and eosin (H&E) displayed a normal structure in the 2- and 10-month groups, whereas in the 30-month group, we observed hypertrophy and, at 60 months, muscle disorganization and atrophy. (B) The number of myocytes decreased with age. (C) The width of the myocytes increased at 10 and 30 months. (D) Light microscopy images of longitudinal sections stained with Van Gieson (VG) highlighted collagen infiltrations in red. (E) Collagen content exhibited a significant increase in 60-month-old fish. (A,D): scale bar = 100 μm (above) and 50 μm (below). Data are presented as mean ± SEM (n = 4 animals/group). * p < 0.05 vs. 2 mo; *** p < 0.001 vs. 2 mo; ## p < 0.01 vs. 10 mo; ### p < 0.001 vs. 10 mo; $$ p < 0.01 vs. 30 mo; $$$ p < 0.001 vs. 30 mo. One-way ANOVA with a Tukey’s post hoc test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.