FIGURE

Fig. 6

ID

ZDB-FIG-240522-18

Publication

Madakashira et al., 2024 - DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish

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Fig. 6

dnmt1 depletion rescues DNA replication defects in uhrf1 mutant hepatocytes. (A) Representative images of 120 hpf uhrf1−/− and control embryos uninjected or injected with dnmt1cr. (B) Quantification of the left liver lobe area of 120 hpf uhrf1−/− and controls uninjected or injected with dnmt1cr. (C) qPCR of key cell cycle genes in 120 hpf livers of uhrf1−/− and controls uninjected or injected with dnmt1cr. (D) 30 minute EdU incorporation at 120 hpf in uninjected and dnmt1cr injected controls and uhrf1−/− livers. Scale: 50 μm in B, 1000 μm in C, the number of samples and clutches indicated for each condition P-value *< 0.05, **< 0.005, *** < 0.0005 by unpaired Student's t-test with adjustment for multiple comparisons and represented as median with range

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.