FIGURE

Figure 1

ID

ZDB-FIG-240429-120

Publication

Muscò et al., 2024 - Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development

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Figure 1

Multiple in silico approaches unveil conservative features between PRR12 and its orthologs in zebrafish. (A) Schematic representation of human PRR12 protein highlighting the main acknowledged domains (modified from Chowdhury et al. [7]), together with a multiple sequence alignment of the amino-terminal proline-rich (black box; 35% identity Prr12a-201 and Prr12b-201 vs. PRR12), AT-hook (black dashed-line boxes; AT-hook 1168–1180aa: 91.66% identity Prr12a-201 and Prr12b-201 vs. PRR12; AT-hook 1202–1214: 66.67% identity Prr12a-201 and Prr12b-201 vs. PRR12) and DUF4211 (black squared brackets; 60% identity Prr12a-201 and Prr12b-201 vs. PRR12) functional motifs of the human and zebrafish Prr12a-201 and Prr12b-201 proteins. Abbreviations: Hsa:Homo sapiens; Danre: Danio rerio. (B) Syntenic relationship between human PRR12 and zebrafish prr12a and prr12b loci. A total of six genes is conserved in prr12b surroundings compared to chromosome 19. A poor synteny in conversely evidenced for prr12a locus. Chr: chromosome.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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