FIGURE

Fig. 3

ID

ZDB-FIG-240426-10

Publication

Zhang et al., 2024 - Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model

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Fig. 3

Verification of molecular mechanisms after immersion in BAPN induction in adult zebrafish. A, exhibits a histogram illustrating the relative expression levels of CNN1a, CNN1b, ACTA2, and TAGLN in control and BAPN-treated zebrafish, as determined by qPCR. Statistical significance was assessed using an unpaired t-test, with a sample size of 3 zebrafish per group and a total of three groups (*P < 0.05; **P < 0.01). B, Principal component (PC) analysis. C, presents a volcano plot illustrating all the differentially expressed genes (DEGs). D and E, KEGG pathway enrichment analyses for up- and downregulated differentially expressed genes (DEGs). F, encompassed Reactome Gene Set Enrichment Analysis (GSEA), with a cut-off p-value set at 0.05. Heatmap for DEGs annotated as (G) ‘smooth muscle phenotypic transformation’ and (H) ‘oxidative phosphorylation’ in the KEGG database.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Animal Cells Syst (Seoul)