FIGURE

Fig. 4

ID

ZDB-FIG-240419-53

Publication

Li et al., 2024 - A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo

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Fig. 4

Hecubine affected the secretion and protein levels of inflammatory cytokines in LPS-stimulated BV-2 cells. Cells were pretreated with Hecubine for 1 h and then exposed to LPS for another 24 h. The production of TNF-?, n = 8 (a), IL-6, n = 6?8 (b), IL-1?, n = 4 (c), MCP-1, n = 4 (d), and IL-10, n = 4 (e) in the cell culture medium was determined by ELISA. (f?h) The protein expression levels of TNF-? (n = 4) and IL-1? (n = 3) were measured by Western blot analysis. ? and + represent the absence and presence of LPS (800 ng/ml), respectively. The data are presented as the mean � SD of three independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. LPS-treated group; ###p < 0.001 vs. control; One-way ANOVA with Dunnett?s multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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