FIGURE

Fig. 4.

ID

ZDB-FIG-240408-34

Publication

Furukawa et al., 2024 - Gluconeogenesis in the extraembryonic yolk syncytial layer of the zebrafish embryo

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Fig. 4.

Possible metabolic pathways in YSL found in this study. The pathways originating glutamate (Glu), lactate, and both are labeled with (a), (b), and (c), respectively. Glu is converted to α-ketoglutarate (αKG) by glutamate dehydrogenase (GDH), metabolized through Krebs cycle to oxaloacetate (OAA), and used to produce phosphoenolpyruvate (PEP) via PEPCK-M reaction, while this enzyme hydrolyzes mtGTP. Here, succinyl-CoA synthetase (SCS) in Krebs cycle provides mtGTP, labeled with (d). Lactate, following conversion to pyruvate, enters Krebs cycle by two separated pathways: to OAA via pyruvate carboxylase (PC) or to acetyl-CoA via pyruvate dehydrogenase (PDH). The former provides new Krebs cycle intermediate, while the latter only helps revolution of this cycle. Considerable amount of citrate is likely transported out of mitochondria and metabolized back to pyruvate via ATP-citrate lyase (ACL), malate dehydrogenase (MDH), and malic enzyme (ME).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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