FIGURE

Figure 6.

ID

ZDB-FIG-240405-62

Publication

Zhou et al., 2024 - Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

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Figure 6.

Network pharmacology and molecular docking analysis of VLZ activity in thrombocytopenia.

(a) Venn diagram of the common targets of VLZ and thrombocytopenia. (b) The VLZ-targets-Thrombocytopenia network that was constructed by Cytoscape_v3.7.1 software. (c) Protein-protein interaction (PPI) network based on the core targets of VLZ against thrombocytopenia through the screening conditions of Degree >12, BC >0.01105525, CC >0.52777778. (d) Molecular docking shows the binding ability between VLZ and its core targets (MAPK1 and SRC). (e) Visualization of cellular component, biological process, and molecular function enrichment analysis. (f) The top 10 of CC, BP, and MF terms showing the greatest enrichment with VLZ-related processes are listed in ascending order of P values.(g) The top 20 of KEGG pathways enrichment analysis for the mechanisms of VLZ against thrombocytopenia. A higher richness factor indicates more enrichment. The number of genes enriched in each pathway is represented by the size of the bubble. The p value range is shown by the color of the bubble.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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