FIGURE

Fig. 4

ID

ZDB-FIG-240405-11

Publication

Salgado-Almario et al., 2023 - ERG potassium channels and T-type calcium channels contribute to the pacemaker and atrioventricular conduction in zebrafish larvae

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Fig. 4

Second-degree AV block of Mobitz type I in a representative 3 dpf zebrafish larva induced by the T-type Ca2+ channel antagonist ML218 (0.3 mM). (A) Emission ratio images before (basal) and after treatment with 0.3 mM ML218 for 1 h. The calibration squares are as described in Figure 1. (B) Atrial (red) and ventricular (gray) Ca2+ levels (emission ratio) before and after treatment with ML218. The red- and gray-dashed lines indicate the start of atrial and ventricular Ca2+ transients, respectively. (C) AV delay before and after treatment with ML218. (D) Time course of ventricular diameter before and after treatment with ML218. In this experiment, images were acquired at 100 frames/s.

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