FIGURE

Figure 7

ID

ZDB-FIG-240331-63

Publication

Stoyek et al., 2024 - POPDC1 Variants Cause Atrioventricular Node Dysfunction and Arrhythmogenic Changes in Cardiac Electrophysiology and Intracellular Calcium Handling in Zebrafish

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Figure 7

Effects of ISO on V_m and Ca²⁺ dynamics in larval zebrafish. (A) AP upstroke speed (upper row) and APD₈₀ (lower row) and (B) CaT upstroke speed (upper row) and CaTD₈₀ (lower row) in WT (n = 58 and n = 54, N = 5), popdc1^S191F (S191F; n = 47 and n = 56, N = 5), and popdc1^KO (KO; n = 55 and n = 54, N = 5) from the atrium (left column) and ventricle (right column) of zebrafish larvae with a moderate morphological phenotype. Groups were compared by the non-parametric Kruskal–Wallis test, with Dunn’s corrected post hoc tests for multiple comparisons (* p < 0.05, ** p < 0.01, **** p < 0.0001), and to values pre-ISO (from Figure 4 and Figure 5) using unpaired two-tailed Student’s t-tests (^#p < 0.05, ^###p < 0.001, ^####p < 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genes (Basel)