Figure 7

Figure 7

Effects of ISO on V_m and Ca²⁺ dynamics in larval zebrafish. (A) AP upstroke speed (upper row) and APD₈₀ (lower row) and (B) CaT upstroke speed (upper row) and CaTD₈₀ (lower row) in WT (n = 58 and n = 54, N = 5), popdc1^S191F (S191F; n = 47 and n = 56, N = 5), and popdc1^KO (KO; n = 55 and n = 54, N = 5) from the atrium (left column) and ventricle (right column) of zebrafish larvae with a moderate morphological phenotype. Groups were compared by the non-parametric Kruskal–Wallis test, with Dunn’s corrected post hoc tests for multiple comparisons (* p < 0.05, ** p < 0.01, **** p < 0.0001), and to values pre-ISO (from Figure 4 and Figure 5) using unpaired two-tailed Student’s t-tests (^#p < 0.05, ^###p < 0.001, ^####p < 0.0001).