FIGURE

Figure 1

ID

ZDB-FIG-240331-57

Publication

Stoyek et al., 2024 - POPDC1 Variants Cause Atrioventricular Node Dysfunction and Arrhythmogenic Changes in Cardiac Electrophysiology and Intracellular Calcium Handling in Zebrafish

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Figure 1

Morphological phenotypes and survival of zebrafish larvae. (A) Examples of 7 dpf WT and popdc1^S191F (S191F) larvae with normal morphology (no phenotype) or a moderate morphological phenotype, involving spinal (Sp) curvature and/or pericardial (Pc) effusion. (B) Survival of WT (n = 2005 larvae, N = 22 clutches), popdc1^S191F (n = 2469, N = 20), and popdc1^KO (KO; n = 1740, N = 19) larvae over the first 7 dpf. (C) Incidence of larvae with normal morphology or a moderate or severe morphological phenotype (spinal curvature, pericardial effusion, or both) in surviving larvae (WT = 1774 survivors; popdc1^S191F = 1670; popdc1^KO = 879) at 7 dpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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