FIGURE

Fig. 7

ID

ZDB-FIG-240301-19

Publication

Zhao et al., 2023 - Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals

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Fig. 7

Crosstalk between Yap with Hh signaling factors. Upon Hippo pathway inactivation, activated YAP/TAZ translocate into the nucleus and interact with the TEAD family transcription factors, thereby by promoting the expression of target genes of YAP, including Ankrd1, Ctgf, Areg, etc. VP inhibits YAP through direct binding with its cofactor TAZ, thereby inhibiting the interactions with its downstream cofactors, TEAD. Inhibition of Yap exhibited suppression effect on TAA-induced Shh, Smo, Gli1 and Gli2. YAP yes-associated protein, TAZ transcriptional coactivator with PDZ-binding motif, VP verteporfin, Smo smoothened, SHH sonic hedgehog, PTCH1 patched 1, Gli GLI family zinc finger, Ctgf connective tissue growth factor, Areg amphiregulin; connective tissue growth factor, Ankrd1 ankyrin repeat domain 1

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Commun. Signal.